What’s Unique About the New Standard Nexera X2 System? 

The Nexera Quaternary system can deliver low-pressure gradient mixtures of five solvents. Its ability to fill up to five types of mobile phases in one solvent delivery unit terminates the time and trouble of exchanging mobile stages during method development. Suppose a low-pressure gradient unit is added to a system with two solvent delivery units. In that case, both binary and quaternary capabilities can be achieved in a single system, improving instrument utilization efficiency. 

Smooth Migration from General-Purpose HPLC Systems

The Nexera X2 offers both Shimadzu UHPLC System and HPLC capacity with a single system. Regular Nexera Quaternary system configurations with one solvent delivery unit can gradient analysis using up to four solvents. Furthermore, existing HPLC methods can be reproduced on the system and migrated to UHPLC methods. 

Up to 16 Possible Mobile Phase Combinations

Suppose a Nexera Quaternary system equipped with two solvent delivery units is available. In that case, four different mobile phases can be loaded for each solvent delivery unit, which means a maximum of 17 gadget phase combinations can be recommended. Since that eliminates the manual operations required to exchange mobile phases each time, mobile phase conditions are changed. It can reduce the number of labour hours needed to prepare mobile steps.

Simplifies Time-Consuming Method Development Processes

The Nexera procedure Scouting method development system, which can accommodate up to six columns and eight mobile phases, can automatically switch between up to 96 combinations of columns and mobile steps. This means data can be received at any time, typically down-time, thus making highly efficient method development possible.

Not Only Automates Data needed, but Significantly Reduces Labor Required for Preparation

The Nexera Method Scouting system can significantly reduce the labour hours required for preparation and avoid logical errors in setting up method files and schedule procedures. Having in mind, it can accommodate up to six columns, nine types of mobile phases, and ten gradient settings; it can provide 90 combinations. Setting method file and schedule settings manually would not only take time but could result in inadvertent errors.

Solvents used in mobile level blending can also be considered in a database, in the same way as for scouting. This allows you to select them keenly via a graphical user interface.

UHPLC/HPLC Switching element Allows a Single System to Handle Both UHPLC and HPLC

This system is especially useful for users who want to quickly develop methods with UHPLC and then deploy those methods horizontally to existing Shimadzu UHPLC Systems. Using a flow line switching valve to switch between dedicated UHPLC and HPLC mixers automatically, a single LC material can be used for both UHPLC and HPLC applications, thus reducing the costs of introducing and maintaining different systems. 

With its flexibility in solvent delivery methods, the Nexera X2 offers a mobile phase blending function capable of blending solvents at any mixture ratio desired. Mobile phase blending can be used to automate preparing buffer solutions, diluting solvents, adding acids, and so on. Method development or robustness evaluation may require preparing many different types of mobile phases in small quantities. In such cases, the mobile phase blending function can automatically qualify only the amounts necessary for analysis. This helps improve the amount of work required for preparation and solvent consumption, making the process more environmentally friendly.